Since the 1990s, medical professionals have recommended that women who can become, plan to be, or are currently pregnant should be supplementing with folic acid to ensure a healthy fetal development and lower the risk of neural tube defects, congenital heart defects, low birthweight, preterm birth, and birth defects like spina bifida (PMC3257747).
However, recent research has shown that folic acid supplementation is not always the best option, as is it estimated that up to 40% of the world's population has a genetic mutation that inhibits folate and its derivatives from being metabolized by the body.
When this happens, folate continues to circulate throughout the body without being utilized properly, which can result in either a folate deficiency and/or folic acid toxicity. This is the opposite of what we want for pregnant women and their developing fetuses.
Furthermore, women who are deficient in folate have a higher risk of mental health issues like depression, schizophrenia, and bipolar disorder (PMC9433753), as well as sleep disturbances like insomnia (PMC8974368), all of which can be detrimental to a pregnant mother.
One of the easiest ways to minimize these risks is to take methylated folate instead of folic acid during your childbearing years.
In this article, you will learn:
Folate plays a vital role in a healthy pregnancy, especially in the first month of pregnancy.
Folate is responsible for neural tube development in early pregnancy (the first trimester), as well as DNA synthesis and red blood cell formation.
In fact, the neural tube closes just 28 days after conception (PMC3257747), so getting enough folate through diet and supplementation before you get pregnant is especially important.
But folate isn't just for the baby, it's also for mama, too. Mama needs folate to keep up with the increasing blood volume throughout pregnancy. Adequate folate levels ensure that there are enough red blood cells in the blood, and folate insufficiencies affect how iron is distributed in the body, which can lead to iron deficiency anemia as well.
Other complications like recurrent miscarriages (PMC6094536), depression (PMC9433753), heart disease (PMID12387655), and gestational diabetes (Liu, P., 2020) can also occur if mama does not have adequate levels of folate and/or methylation issues.
The terms 'folate' and 'folic acid' are commonly used interchangeably, but there is a distinct difference between the two and they are not the same thing.
'Folate,' also known as vitamin B9, refers to the naturally occurring form of the water-soluble vitamin found in foods. The human body cannot create or store folate, so it must be consumed from the diet daily. In addition, the human body cannot use the natural form of folate; it has to be methylated, or converted, into the active form of methylfolate to be used by the body.
Folate is required for the creation, maitainance, and division of cells, the production of DNA, cardiovascular health, mood, and cognition. It is also commonly recognized as one of the most essential nutrients for pregnant women because of its role in cell division and DNA production for the growing fetus.
'Folic acid' is the synthetic form of folate. It is not found in nature, meaning it is not inherently found in food, but it has been conclusively shown to be more absorbable than natural folate, and as such, has been added to many staple foods in the United States like grains and cereals.
For decades, folic acid has been the main source of dietary consumption of folate, and it has also been widely prescribed to women of childbearing age to prevent deficiency as a protection for the unborn child.
So why is there a debate?
The important thing to understand with all of this is that both folate and folic acid must be converted to the biologically active form, methylfolate (also known as methyltetrahydrafolate or 5-MTHF), in order to be used by the body. If that essential conversion process is inhibited, altered, or broken in some capacity, it doesn't matter which form of folate (either folate or folic acid) you consume because it won't be completely or efficiently converted to the usable form your body (and your unborn baby) needs to thrive.
Dr. Lorena Carboni points this out in her research when she says: "folate deficiency is incredibly common and may occur when: (1) dietary intake is inadequate; (2) an increased need isn’t matched by increased intake, as in physiological conditions such as pregnancy, lactation, and children’s growth; (3) absorption or excretion is altered or losses occur; or (4) metabolism or drug use interfere with the body’s ability to use folate" (PMC9380836).
As of February 2025, the current dietary recommendation for folate for pregnant women is 600 mcg/day, although some researchers and practitioners believe at least 900 mcg/day is more supportive for pregnancy.
On most nutrition labels, you'll see something like "600 mcg DFE." 'DFE' stands for dietary food equivalent, and it meant to show the relativity of different types of folate, including folic acid.
Per the National Institute of Health, "the current RDAs for folate as mcg of dietary folate equivalents (DFEs). The FNB developed DFEs to reflect the higher bioavailability of folic acid than that of food folate." As such:
The NIH also notes that "factors for converting mcg DFE to mcg for supplemental folate in the form of 5-MTHF [or folinic acid] have not been formally established."
It should be noted that the tolerable upper limit is 1,000 mcg of folic acid per day, so it's important that if you do choose to use folic acid as your form of folate, you're staying between 600-1,000 mcg folic acid. We want adequate folic acid, but we don't want too much folic acid either, as studies suggest that high serum folate levels could have the same effect as low serum folate levels.
What does this mean? This means that too much folic acid could actually trigger an outcome that mirrors folate deficiency, which is NOT ideal for any pregnant woman or unborn baby.
This is why it's important to monitor how much you're getting from your supplement(s). Thankfully, it's nearly impossible to approach the upper limit of folate through just a balanced diet alone, so you really only need to pay attention to your supplements and how much "fortified" or "enriched" foods you're consuming.
Because there are many different forms of folate, there are many different ways to get enough folate, especially methlyfolate, whether that's through a healthy diet of whole foods or a folate supplement.
(It should also be noted that while you can have too much synthetic folic acid, it's near impossible to consume too much folate through whole food sources, which is why a diet rich in folate is so important for mama and baby.)
Some sources of natural food folate are:
Sources of food-based folic acid include breakfast cereals, grains, and enriched flours, and you can know right away if they have folic acid in them if the packaging says "enriched" or "fortified."
If you want to minimize your consumption of folic acid, which I recommend, here's what you can do:
In my professional opinion and based on current research (as of February 2025), I believe methylfolate is better. This is because it is the biologically active form of folate that your body needs to thrive and it skips the methylation process, which means you're getting the most amount of usable folate possible.
MTHFR stands for methylenetetrahydrofolate reductase, an enzyme responsible for breaking down the amino acid homocysteine.
Every person has the MTHFR gene, but many people have mutations or variations on this gene that impair the MTHFR enzyme from doing its job properly. This increases their risk for cardiovascular disease, dementia, mood disorders like depression, anxiety, and bipolar, and neural tube defects in developing fetuses.
There are many different variants of the MTHFR gene, but the majority of people with genetic variants have one or both of two specific variants discussed below.
While there have been multiple MTHFR variants discovered (Table 5, NBK6561), only two have been confirmed to affect overall health status and be present in a significant portion of the population: C677T and A1298C.
Certain chronic conditions have been linked to each genetic variant, but the overall conclusion from multiple areas of research is that these genetic mutations of the MTHFR gene increase a person's risk for multiple health conditions, and as such, should be a consideration in an individual's prenatal health care.
For example, one observational study found a statistically significant relationship between the C677T mutation and an increased risk of hypertension and elevated blood pressure, and an even higher risk if coupled with a riboflavin deficiency (BMC Medicine, 2020).
No matter which type of mutation you have, the severity of the mutation depends on whether or not you have a homozygous mutation or a heterozygous mutation. The latter is correlated with more health complications.
In my professional opinion, I believe that the most bioavailable form of folate is the best option for you because it's the only form of folate that your body can use. It doesn't use folic acid or folate, it converts both folic acid and folate to 5-MTHF (methyltetrahydrafolate) to be used in the body.
In addition, it's estimated that 40% of the world's population has the genetic mutation, which is 2/5 people, so it's almost a coin toss of whether or not you have the mutation.
That being said, in the United States, the current standard of care and official recommendation by the CDC and ACOG is folic acid and that's where the majority of research funds and expertise has been put towards.
The most confusing part is when I Googled "can you metabolize folic acid if you have MTHFR," I got completely opposite answers from multiple credible sources:
A common rebuttal is that "folic acid is the only type of folate shown to help prevent neural tube defects," but there are a few limitations with this argument:
Because there isn't enough research about other types of folate, the only possible conclusion can be that folic acid is the only safe option for pregnant women. This doesn't automatically mean that other forms of folate are ineffective or dangerous, it just means there isn't enough conclusive evidence from funded research. In fact, Lily Nichols, a registered dietitian, industry leader, and three-time best selling author noted that "testing the efficacy of 5-methylTHF against a placebo would be unethical. Comparing the preventive effect of folic acid with a proposed better alternative (5-methylTHF) will require following several thousands of pregnancies over a long time. The costs of testing 5-methylTHF against folic acid would be extremely high. We do not have any reason to assume that a randomized controlled trial is justified before recommending 5-methylTHF” (Lily Nichols).
Methyfolate accounts for up to 95% of the folate in your blood as well as the majority of the natural folate found in your food and almost all of the folate in umbilical cord blood. If this is the case, why wouldn't methylfolate be a safe and appropriate option?
High or optimal amounts of folic acid in your blood just means there's a lot of folic acid present. Whether or not your body can actually use all of that folic acid is another story, and blood work doesn't always reflect that. Folate is an intracellular nutrient, which means it has to be transported into your cells to take effect. Because of this, "it doesn’t matter how much of a vitamin exists in or out of the cell if that cell is incapable of utilizing that nutrient... Measuring levels instead of function would be akin to measuring the amount of fuel in the engine (cell) and discovering the car still won’t drive (function) because it didn’t need gas, it needed oil. Gasoline levels would be fine in the engine, but the engine still won’t function if gas is not what it needs" (SpectraCell Labratories). This means that the best way to test folate, an intracellular nutrient, is by testing the tissues, not the blood. In fact, researchers tested serum folate levels vs folate levels in the tissue and found that "the plasma values do not accurately reflect tissue values" (PMC3786706).
Lastly, it takes anywhere from 15-20 years to update national dietary/supplementation recommendations and guidelines and even longer to implement them, so just because the CDC says something doesn't mean that's the most current and best-practice recommendation today.
This article from Needed does an incredible job at answering questions like "what research exists around the effectiveness of folate supplementation?" and "if I know I don’t have the MTHFR variant, is folic acid better?" and "if L-methylfolate is superior, why do major medical organizations recommend folic acid?" so I encourage you to read the aforementioned article as part of your research in addition to this article.
Another factor to consider is minimizing postpartum hair loss. Folate and vitamin B12 have been "associated with hair loss" and a small study in the Turkish population found that patients with alopecia and >20% total hair loss also showed "red blood cell folate concentrations [that] were significantly lower in the patient group than in controls" with "a higher prevalence of mutations in the [MTHFR] gene" (PMC6380979).
This leads me to believe that your risk of severe postpartum hair loss is higher if you have the MTHFR gene mutation and are not properly supplementing for it.
At the end of the day, it's up to YOU and YOUR MEDICAL PROVIDER to make the decision about what's best for you, your baby, and your health. After all, we're not talking about laws here, we're talking about guidelines. I've quoted the current standard of care but I've also shown a bunch of newer research that says something else. It's up to you and your doctor to sort through the information and your medical history and make the best decision for you and your baby.
Please remember that it's meant to be a conversation, not just a "talk to me and I'll just take your word for it" moment. It's 100% OK and encouraged to take independent research and articles like this one to your doctor and say, "I wanted to make a decision that's best for me and I found some things I'd like to talk to you about. Here's what I found [...] and here's what I'd like your thoughts on [...]."
I did this with my hernia surgery in February 2024. I had one surgeon tell me I'd have to completely stop breastfeeding and switch to formula to have the surgery due to necessary medications during and after the procedure and I wanted to know if that was just his opinion or the cold, hard truth.
After research and multiple other conversations with other medical professionals, I realized that wasn't true and I could continue breastfeeding and still have the procedure done!
If you want to hear how I navigated researching information, talking with doctors, and advocating for my health, listen to episode 28 of The Well Nourished Mama Podcast!
The easiest way is genetic testing, but that's usually not covered by insurance and it can be pretty pricey out-of-pocket.
Another way to see if you have the MTHFR genetic variation is requesting blood work through your doctor to check your homocysteine levels.
After folate is metabolized by the body, it is converted into homocysteine. Chronically elevated levels of homocysteine are generally an indication that you are deficient in B vitamins, which could be a result of poor methlyation.
Repeat studies have shown that elevated homocysteine levels are a strong indication of an existing MTHFR gene mutation, and checking homocysteine in a standard blood panel is quite simple and affordable; you just have to specifically request it.
Because there are so many prenatal vitamins on the market, it's important to know some of the important things to look for in a brand:
The more, the better. If a brand has third party testing, this means they are spending time and money on independent programs that offer inspections and testing of their "manufacturing sites, raw materials, and finished products." Third-party certification provides an "unbiased verification of their product’s quality" (FullScript).
Some common third party certifications are certified gluten free, leaping bunny certified, certified B corp, certified vegan, certified non-GMO, USDA organic, and NSF certified.
In context of this article, this arguably is the most important factor in a prenatal vitamin. This means that the form of both folate and vitamin B12 is activated and does not need to be converted by the body to use.
When reading the ingredient label, look for "methylfolate" and "methylcobalamin."
Similarly to methylated vitamin B, the more nutrients that are provided in their most bioavailable form, the higher the absorption rate in your body and the easier it is for your body to use the vitamins and minerals you're consuming.
Another reason activated, bioavailable forms of nutrients is important is because if you need to convert the nutrient after consumption, by definition that means you need cofactors (other nutrients) to make that conversion possible. This means more variables in the equation and a higher risk of poor absorption.
In short, it's just easier for your body if you give it exactly what it needs without any strings attached.
A classic example of this is the two forms of vitamin A: retinol and beta-carotene. Retinol is the activated, bioavailable form of vitamin A that is ready to use, and beta-carotene needs to be converted into retinol before your body can use it. The better type of vitamin A in your prenatal is retinol.
Another example is vitamin D. You want your prenatal to contain vitamin D3, not D2, because vitamin D3 (cholecalciferol) is the active form and D2 (ergocalciferol) is the less-bioavailable form.
There are SO MANY BRANDS out there that claim to be the best so I want to simplify things for you. Instead of choosing "one clear winner," I'm just going to share the pros and cons of every brand I can find that uses methylated B vitamins for their prenatal vitamin.
Why? Because you are a unique woman with individual needs and outside of the requirement for methylated B vitamins, there are so many other factors you need to consider when choosing your prenatal vitamin like availability, price, and bio-individual needs.
(As always, please consult with your healthcare provider before beginning any supplement and monitor your symptoms as you take your prenatal vitamin. This article is not meant to replace medical advice from a certified professional. It is to be used for educational purposes only. For more information, refer to my privacy policy.)
Now let's get into the best prenatal vitamins for the MTHFR variant. I scoured the internet for every brand I could find that met the above criteria for a prenatal vitamin and compared their nutrient dosages and combinations, availability, and price points to give you a thorough analysis of each brand so you can choose the one that's best for you. I also included links for every brand as well as discount codes if I have them.
Needed is my favorite perinatal supplement brand because their formula was developed by two perinatal nutritionists who collaborated with OBGYNs, registered dietitians, and naturopathic doctors to comb through the latest research and build a vitamin that truly met the needs of both mama and baby.
Their prenatal vitamin contains the optimal dosages for 23 essential nutrients in the most bioavailable forms for maximum absorption. It also does not contain iron or omega-3s, which increases absorption of all other nutrients and allows for targeted supplementation.
Another thing I love about Needed is that they have two forms of their vitamin available -- capsule and powder -- so even if you experience nausea, you still have a way of getting in your nutrients.
The current price point of Needed is $1.80/serving for a one-month delivery schedule.
You can shop Needed using my code "mama20" and get 20% off your first month of any new subscription.
Ritual is another popular brand that focuses on traceable, sustainable, and transparent sourcing of their ingredients and higher dosages. Their formula contains 12 nutrients for mama, including minerals like iodine and magnesium.
However, their formula does contain omega-3s and iron.
Overall, while the quality and sourcing of ingredients is impressive, this brand doesn't have all the essential nutrients for pregnancy and the dosages aren't as high as they could be.
Their current price point is $1.30/serving for a one-month delivery schedule.
I've always been impressed with Perelel because they have slightly different formulas depending on what stage of motherhood you're in.
For example, they have packs for fertility, 1st trimester, 2nd trimester, 3rd trimester, and postpartum, each one with a unique combination of nutrients based on the current needs of mama and baby.
Within each pack is individual serving packs, making your daily routine that much simpler.
I also love that their brand was built by board certified OBGYNs, dietitians, and maternal fetal medicine doctors.
Their current price point is $1.65/serving for a one-month delivery schedule.
WeNatal is another brand I'm very impressed with because they focus on mama, baby, AND dad. Their brand is all about supporting both partners throughout their fertility journey and into pregnancy.
Just like Needed, WeNatal's formula has more than 20 essential nutrients in optimal dosages and was formulated by leading experts in both medicine and nutrition.
Another differentiator of this brand is that their prenatal comes in a refillable glass container, and we all love sustainability!
Their current price point is $2.00/serving for a one-month delivery schedule.
Thorne is an incredible and reputable brand for many different supplements, so I was happy to see they had a prenatal as well.
Their formula is comparable to most other high end prenatals -- high quality ingredients, optimal dosages, and tons of nutrients -- but it does contain iron, which is worth noting.
I do want to point out that in addition to the folate in their prenatal, you can purchase folate separately as 5-MTHF, which could be beneficial if you need additional support.
Their current price point is $1.07/serving for a one-month delivery schedule.
MegaFood stands out for a few reasons: they include whole foods in their formula and their formula contains choline, which isn't a nutrient that every prenatal vitamin has.
That being said, their formula does contain iron as well.
Their current price point is $0.90/serving for a one-month delivery schedule.
Natalist is similar to Perelel where they provide your daily dosage in individual packs, which is convenient, and they have 20+ essential nutrients for mama.
However, their formula contains iron and the price point is one of the more expensive ones.
Their current price point is $2.00/serving for a one-month delivery schedule.
I'm obsessed with Birthright's prenatal because every nutrient comes from animals or real whole foods. The animals are grass-fed and finished and sustainably sourced from regenerative farms and the herbs are wild harvested and freeze dried to retain as much nutrition as possible.
It might not have the impressive array of nutrients like some other brands, but I think the bioavailability and sourcing makes up for it. It also allows you to use targeted supplementation for other nutrients if you want to, which makes your routine more customizable.
Their current price point is $2.27/serving for a one-month delivery schedule.
I love Pink Stork products because they're organic, sustainably sourced, and comprehensive for mama's health in every stage of motherhood.
Their prenatal is no different -- it contains 100% of the recommended daily intake of 20+ nutrients, it has probiotics included to support gut health, and ginger root to help with morning sickness.
It's also one of the more affordable ones, especially if you use my link and discount code!
Additionally, you can purchase liquid folate separately, which increases absorption and targeted nutrition.
Their current price point is $1.20/serving for a one-month delivery schedule.
You can shop Pink Stork HERE and use my discount code "brooke" to save 20% on your order!
BabyRX is a great option if government-backed supplements is important to you. They proudly claim that their products are made in an FDA-registered facility and formulated by board-certified OBGYNs.
The dosages for the 15+ ingredients are pretty great, but their formula does contain a higher dosage of iron than most, so that's something to consider.
Something I love about this specific formula is that they included collagen for skin and pelvic floor elasticity, and their website has clinical studies linked to each ingredient to help you understand why that ingredient is included in their formula.
Their current price point is $1.16/serving for a one-month delivery schedule.
I love FullWell because they have 20+ bioavailable nutrients AND they omitted both iron and omega-3s. I also love that their doses of vitamin D3 and vitamin B6 are much higher, and they use vitamin K2 instead of K1 to increase absorption of vitamin D.
The only potential downside is that one serving is 8 capsules, but they do say that you can spread your dosage out throughout the day if you need to.
Why 8 capsules? Their formula is comprehensive and has optimal levels of nutrients, not the bare minimum. It's a fantastic thing.
I know I'm not supposed to say which brands are the best, but FullWell is definitely near the top!
Their current price point is $1.50/serving for a one-month delivery schedule.
Ancient Nutrition's prenatal is unique because in addition to the basics like methylated B vitamins, their formula also contains beef and chicken bone broth, bovine liver, and wild hake roe (fish eggs), and the latter two ingredients are sourced from New Zealand, one of the highest quality sources in the world.
A possible downside is that many of the essential vitamins and minerals are sourced from plants, which means they have to be converted to be used, but they're sourced from high quality whole foods, which makes them as bioavailable as possible given the circumstances.
Their current price point is $1.42/serving for a one-month delivery schedule.
I love Mary Ruth's Organics because their supplements are organic and LIQUID. Making the prenatal liquid increases the absorption rate and makes it easier on the stomach, too.
The only limitation is that you can only have so much stuff suspended in liquid, so their formula naturally has lower dosages than other brands, but the bioavailability is high and it might be more tolerable if you have bad nausea, too.
They also have two options: one without iron, and one with iron, which makes targeted supplementation that much easier.
Their current price point is $1.35/serving for a one-month delivery schedule.
This brand's differentiating factor is that their formula focuses on brain health for baby. Best Nest Wellness has higher levels of B vitamins and a decent amount of microminerals, too.
I also love that they have a few strains of probiotics in their formula to increase absorbability and support mama's gut health.
The only downside I see is that their vitamin D dosage is pretty low and their formula includes iron.
Their current price point is $1.29/serving for a one-month delivery schedule.
If you prefer a vegan or plant-based prenatal, Future Kind would be a great option for you.
While their formula doesn't contain as many nutrients or high dosages of each nutrient, they do have a substantial amount of B vitamins, which is especially important for vegans, and their ingredients are sustainably sourced.
Their current price point is $0.87/serving for a one-month delivery schedule.
Inessa is also 100% vegan, but they're UK based, so if you're from the US, you might have to plan ahead a bit more when ordering your prenatal.
This brand has a whopping 26 nutrients in its formula, and I love that they has CoQ10 too, which is a really important nutrient for fertility and optimal egg quality. I haven't seen a brand include CoQ10 in their prenatal formula before!
Something else I loved in their disclaimer section was this: "Like most practitioner-grade supplements, we don’t include calcium and magnesium in our pregnancy formula. The large molecular size of these minerals makes it impossible to fit meaningful amounts into a single capsule. In order to achieve the amounts of calcium and magnesium needed to support a healthy pregnancy, you’d have to take an additional 3-6 capsules per day of a separate calcium and magnesium supplement. A lot of brands do include calcium and magnesium in token amounts to make their formula appear more complete. It goes against our ethos to include ingredients in token amounts, and it misleads the customer into thinking they’re covering their dietary intake needs."
This transparency was a breath of fresh air and I love how clearly they explained the difference in their formula.
Their current price point is $1.29/serving for a one-month delivery schedule.
Beli stands out with all their third party certifications and their high dose of vitamin B6 to help combat nausea. They also have a "prenatal" for dad.
The things to consider with this brand are that they have iron in their formula and they didn't include any vitamin A, either, which is an essential nutrient for pregnancy.
Their current price point is $1.67/serving for a one-month delivery schedule.
I normally don't recommend gummies if you're looking for a high quality prenatal, but I needed to include SmartyPants sugar free prenatal in case you can't tolerate capsules and want an MTHFR friendly gummy.
They have a "regular" and sugar free prenatal, so be sure to choose the sugar free version!
While this brand does have methylated B vitamins, they have hardly any choline in their formula and a low dose of selenium too, which is an essential nutrient for your thyroid. In addition, because it's a gummy formula, there's a lot of extra ingredients to make the vitamins a gummy. Lastly, their main formula has a 20 day supply, not a 30 day supply like every other brand.
It's not my favorite type of vitamin for mama, but it's better than nothing and it's on the list of MTHFR-safe prenatal vitamins!
One positive is that you are more likely to find this brand at Walmart or Target, so it is more widely available than most of the other brands on this list.
Their current price point is $1.20/serving.
I've followed Dr. Jolene Brighten on Instagram for a while and she is amazing. She is a naturopathic endocrinologist who has also battled endometriosis most of her life, she's a best selling author, and she is a wealth of knowledge when it comes to women's health and fertility.
I discovered that she had a line of supplements, including a prenatal, so I knew it was going to make this list.
Not only does her prenatal have 20+ essential nutrients for mama, she also put a heavy focus on optimal thyroid health during pregnancy and postpartum by including the perfect ratio of iodine and selenium in combination with other nutrients.
Their current price point is $1.60/serving for a one-month delivery schedule.
I discovered this brand from an Instagram ad and I was impressed at the quality!
Their Mama Bear prenatal has a wide array of essential nutrients, as well as additional nourishing ingredients like red raspberry leaf powder to support uterine strength, chamomile powder and ginger powder to ease nausea, and dandelion powder for optimal liver function.
The only issue I see with this brand is that there are mixed reviews about the taste/smell. While the overwhelming majority of reviews are a raving 5 stars, there are more than a handful of reviews that said the smell/taste was repulsive. I'm assuming that's because of all the natural herbs? It's worth considering if you know you are particularly sensitive.
Their current price point is $1.26/serving for a one-month delivery schedule.
If you have the MTHFR mutation, it's important to supplement with the active form of folate (not folic acid) during pregnancy. This blog post will help you decide which prenatal vitamins are safe for pregnant women with the MTHFR gene mutation.
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